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The three major routes of administration used for skin lightening are topical (creams, face washes), oral (capsules and sublingual/buccal tablets) and intravenous injections
Drug-induced organ toxicity, where oxidative stress and inflammation lead to cell death and tissue malfunction in the liver, kidney, and gastrointestinal tract, has been linked to Cx43 dysregulation [24]
There is no rebound
Clinical applications include post-procedure recovery (cosmetic surgery, dental surgery, orthopedic procedures), chronic wound support, and athletic recovery from soft-tissue injury
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