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The regulation of the HMGCS2 gene and the encoded enzyme itself are subject to various regulatory processes

[2] Causes are usually related to conditions that give rise to malabsorption of vitamin B 12 , particularly autoimmune gastritis in pernicious anemia

Amyloidosis associated with dialysis occurs when blood proteins are deposited on joints and tendons, resulting in discomfort, stiffness, and fluid buildup in the joints