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Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist widely explored in laboratory and experimental research settings related to metabolic regulation, glucose-homeostasis pathways, appetite-related signaling, and adipose-related research models

We previously described a novel GLP-1 analogue consisting of the fusion of active GLP-1 and IgG heavy chain constant regions (GLP-1/IgG-Fc), and showed that in vivo expression of the protein, via electroporation-enhanced intramuscular plasmid-based gene transfer, normalized blood glucose levels in T2D-prone db/db mice

Richman, P

Until that process finishes, retatrutide can be accessed only through enrollment in a clinical trial