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When mitochondrial function becomes impaired, ROS production may increase while energy production becomes less efficient

Macrophage subsets (MAC.1, MAC.2) were distinguished by high expression of CD68, CEBPB , and FCER1G , while a third cluster (Inf.MAC) expressed NLRP3 and showed an inflammatory, cytokine-enriched, and pro-angiogenic profile with markers like IL1B and CCL3

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