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The growing demand for pharmacological tools to support weight loss, beyond traditional lifestyle interventions, reflect a broader shift in how these powerful medications are being used in clinical practice

Active substance dependence: published trials in opioid- and alcohol-withdrawal contexts were small and used clinical settings, not self-directed protocols

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The group concluded that considering its substrate specificity and expression in organs such as the brain, kidney and intestine, genetic variations in may be an important contributor to inter-individual variability in drug disposition and central nervous system entry of OATP1A2 substrate drugs (Lee et al