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they involve multifaceted effects that concern the entire body
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What the two categories don't share: an FDA-approved branded drug has gone through FDA's premarket safety and effectiveness review
Compared to the common 3 isoform, the 4 variant is the strongest genetic risk factor for late-onset AD (Houlden et al., 1998), while the 2 isoform significantly reduces risk (Reiman et al., 2020)
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