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For researchers comparing epitalons longevity mechanism to other approaches, the critical distinction is that epitalon addresses two hallmarks of aging that most longevity peptides do not: telomere attrition (through telomerase activation) and the loss of circadian regulation (through melatonin restoration)
GSTs that responded to most of the treatments included F6 and F7, as well as many tau types, with U1, U4, U5, U6, U7, U8, U24, and U25 showing a particularly clear induction