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Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) are contraindicated from GLP-1 therapy

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A meta-analysis of 5 RCTs 42,43,44,45,46 comprising 7,732 adults with T2DM did not observe any effect on cognition, as measured via mini-mental state examination (MMSE) or Montreal cognitive assessment (MoCA), of GLP-1RAs over several months compared with the baseline 38

Currently, the manufacturer, Eli Lilly, has conducted TRIUMPH trials to check the efficacy of retatrutide in various health conditions, including obstructive sleep apnea, knee osteoarthritis, and type 2 diabetes