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On the other hand, CPP-CAND, which integrated the positively charged HIV-TAT sequence, demonstrated senolytic activity (Figure

When ligands (such as IS, IAA, and kynurenine) bind to AhR, AhR is released from the chaperone protein complex and translocates to the nucleus, where it heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), then binds to xenobiotic response elements (XRE) or dioxin response elements (DRE) to induce downstream target gene transcription (120)

c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma