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Phase 2 trial (48 weeks, obesity population) Published in the New England Journal of Medicine (Jastreboff et al.), this trial enrolled 338 adults with a body mass index of 30 or higher, or 27-30 with at least one weight-related condition

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Originally developed to manage type 2 diabetes, these medications have become household names thanks to their weight-loss side effects

Emerging hypotheses also suggest a possible role in reducing lymphedema risk in breast surgery patients undergoing axillary lymph node dissection, with or without immediate lymphatic reconstruction, by preventing obesity-induced mechanical pressure on lymphatic vessels [105]