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Cost accounts for some of that - but studies looking at the drivers of early discontinuation consistently identify side effect intolerance and lack of behavioral support as factors independent of cost
Timing optimization: Effects begin 15-30 minutes post-injection and peak at 1-2 hours
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A 2018 review found that in 11 of 14 studies, metformin showed a greater reduction in weight and BMI when compared to placebo
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