Safety in unregulated settings is the bigger concern: there are reports of severe adverse events when high-dose IV glutathione is administered without medical oversight, with non-pharmaceutical-grade products, or in patients with underlying kidney or thyroid disease
Some of the best ways to boost your glutathione consumption are by eating more sulfur-containing cruciferous vegetables, like broccoli, kale, cabbage, Brussels sprouts and cauliflower
Thus, the role of GSH synthesis in the liver and how this impacts the physiology of adult animals has yet to be fully elucidated
This makes the combination logical, but it is important to emphasize that there is not yet a large human trial in which exactly this full stack NMN + TMG + GlyNAC has been tested long-term on hard endpoints such as biological age, disease prevention, or lifespan