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Furthermore, the microenvironment where PDCs function should be considered because linkers impact drug efficacy or binding affinity depending on structural differences of the linkers

This steep Ca 2+ gradient creates a strong driving force for Ca 2+ entry and is maintained by the low Ca 2+ permeability of the resting erythrocyte and high Ca 2+ -extruding capacity through a Ca 2+ ATPase and Na + /Ca 2+ exchanger in the cell membrane