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Careful attention to morphology and to immunohistochemical findings and conventional histochemistry should enable distinction (see differential diagnosis)

In addition, prolonged exposure to pharmacologic doses of long-acting GLP-1 RAs induces tachyphylaxis for the effects on gastric emptying, and that is why nausea vanishes quickly after the beginning of treatment in most patients [19]

[7] Published experience and post-marketing reports suggest that adverse reactions to topical GHK-Cu are uncommon and, when they occur, tend to be mild and localized