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Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss
Orforgliprons Phase 3 ATTAIN-MAINTAIN trial specifically demonstrated that patients could successfully transition from injectable GLP-1s to orforglipron and maintain their weight loss
Furthermore, GIPR antagonists increase metabolism in obese mice, and when combined with GLP1RAs, both GIPR agonists and antagonists have beneficial therapeutic effects
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