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The series does not resolve the lean-mass question with enough rigor to guide clinical decisions about resistance training co-prescription, protein intake targets, or dose modulation to minimize muscle loss
Rare but significant concerns include gallstone disease (12%), especially in the context of rapid weight loss, and acute pancreatitis ( 10% weight loss aligns with lifestyle guidelines and might amplify the effects of secondary agents targeting inflammation or fibrosis
It involves selecting foods that help achieve weight loss goals and avoiding those that hinder progress
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