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From June to July, prescribing increased sharply (+0.11 percentage points), representing the largest single-month increase observed during the study period
These enzymes neutralize superoxide radicals and hydrogen peroxide, reducing oxidative burden
Within seconds of the sensing of increased reactive oxygen species (ROS), several enzymes of glycolysis (particularly glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase) are inhibiting allowing for the diversion of glucose carbons into the PPP
Isocitrate dehydrogenases (IDH) IDH also facilitates the generation of NADPH from NADP + by catalyzing the oxidative decarboxylation of isocitrate to -ketoglutarate (-KG) for TCA cycle
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