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Pain and Physical Function Improvements TRIUMPH-4's co-primary endpoint focused on knee osteoarthritis pain, measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale: WOMAC Pain Score Reductions: Retatrutide 9mg: -4.5 points (75.8% reduction) Retatrutide 12mg: -4.4 points (73.3% reduction) Placebo: -2.4 points (40.3% reduction) Participants also experienced substantial improvements in physical function, with WOMAC physical function subscale scores improving by: Retatrutide 9mg: -4.1 points Retatrutide 12mg: -4.2 points Placebo: -2.1 points Perhaps most remarkably, a post-hoc analysis revealed that 14.1% of participants on 9mg and 12.0% on 12mg became completely pain-free at 68 weeks, compared to just 4.2% on placebo
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It is synthesized from the amino acids lysine and methionine and is primarily stored in skeletal muscles, the heart, and the liver
Semaglutide is available in different forms, such as compounded semaglutide, which is customized for individual patients, and injectable pens like Ozempic and Wegovy
