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PLOS ONE 8 , e58783 (2013)

The addition of glucagon receptor activationabsent from tirzepatide (Zepbound/Mounjaro)may enhance energy expenditure and metabolic effects

However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives