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This lactate propensity implied the vicious circle of sepsis, where patients at their terminal stages always exhibited refractory and critical immunosuppressive effects [156, 158]

Due to the high sequence similarity among Ube2e1, Ube2e2, and Ube2e3, we modeled this region based on the Ube2e2 sequence but removed the side chains (Supplementary Fig

hES-MSCs were also cultured at densities of 2, 3, 4, and 5 10 3 cells/cm 2 followed by functional analysis for oxidant resistance at different culture conditions