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In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine

If youre a woman over 50 thinking about a GLP-1 medication for weight management (or even for prevention, though this is off-label at this time) and your doctor wont prescribe it, youre not alone

Still, researchers caution that findings are largely preliminary and drawn from small cohorts rather than large, sex-stratified clinical trials

Expect unpredictability