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But it makes sense
Once reconstituted, freezing at 20C or 80C creates ice crystal formation that mechanically disrupts the peptide structure and accelerates aggregation upon thawing
Consistent absorption and systemic availability remain uncertain, and human pharmacokinetic data are lacking
In vitro analyses demonstrated a Cys504-Cys504 thiol-disulfide switch that determines distinct conformations of the homotetrameric protein (Gellert et al., 2013)
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