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In heterodimeric GST complexes such as those formed by the cytosolic mu and alpha classes, however, the cleft between the two subunits is home to an additional high-affinity nonsubstrate xenobiotic binding site, which may account for the enzymes' ability to form heterodimers

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Contraindications include personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, or severe renal/hepatic impairment

Glucagon-like peptide-1 (GLP-1) receptor agonists are injectable medications primarily used to manage type 2 diabetes mellitus and, in some formulations, obesity