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A meta-analysis in 2023 examined 93 clinical trials from ClinicalTrials.gov that compared GLP-1RAs direct or indirect impact on DR with placebo, insulin, or oral antidiabetic medications (Kapoor et al., 2023)
Although rates of acute pancreatitis have been low and similar between GLP-1 agonists and placebo in studies, caution is still warranted since acute pancreatitis carries a risk of recurrencewhich can turn into chronic pancreatitiswhich can increase risk of pancreatic cancer
Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos AN, et al
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