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Reported side effects are usually mild and short-lived

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[1] Because it is a large-protein biologic, evolocumab is not metabolized by the cytochrome P450 enzyme family

Bellia F, Lanza V, Naletova I, Tomasello B, Ciaffaglione V, Greco V, Sciuto S, Amico P, Inturri R, Vaccaro S, Campagna T, Attanasio F, Tabb G, Rizzarelli E (2023) Copper(II) complexes with carnosine conjugates of hyaluronic acids at different dipeptide loading percentages behave as multiple SOD mimics and stimulate Nrf2 translocation and antioxidant response in in vitro inflammatory model