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Immunohistochemical examination reveals gonadotropin production in adenoma cells, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and/or a-subunit

If nausea persists beyond 3-4 weeks on a stable dose, consider reducing to the previous dose level and attempting re-escalation more gradually after 4-6 weeks

Preclinical animal studies should report model standardization, timing of intervention, endpoint definitions, histological or functional scoring criteria, and whether investigators were blinded to treatment group