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4 GIP plays an important role in the incretin effect in healthy people
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Given the observed hydrogen-bonding interactions with Q726 and Y524 and considering the contribution of the P-clamp region to PDE10A selectivity, future optimization should prioritize (i) enhancing potency by incorporating structural constraints that properly orient key substituents to reinforce the Q726/Y524 hydrogen-bond network and (ii) modulating lipophilicity and polar surface area to achieve an optimal balance between CNS penetration and effective P-clamp engagement
These findings suggest that NAC when combined with IFN-, has the potential to generate innovative therapeutic modalities for the treatment of endometriosis
