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As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure
Source: US Department of Agriculture, Agricultural Research Service
Studies have displayed that the release of IL-1 and TNF- not only intensifies local oxidative stress levels but also boosts the generation of oxygen free radicals through activating pathways like the NF-B signaling pathway (Luo et al., 2024), (Zhu et al., 2022), (Yucel-Lindberg and Bge, 2013)
Brain Behav 10(8):e01726
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