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It was originally studied in the context of gastrointestinal healing, where the parent protein appears to play a role in protecting the gut lining
Healthcare providers can assess whether the reactions represent true allergic phenomena versus irritant reactions, which have different management implications and may affect decisions about treatment continuation
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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway
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