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For a detailed summary of all model equations, steady-state constraints, observation functions and model parameterization see Supplement

ERF : The ERF study has received funding from the Centre for Medical Systems Biology (CMSB) and Netherlands Consortium for Systems Biology (NCSB), both within the framework of the Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO)

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Consequently , researchers use these models to study how localized blood-flow regulation responds to tissue stress or controlled experimental injury