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A large network meta-analysis comparing weight loss and side effects found more treatment stops at the highest doses, especially due to nausea and vomiting, for both drugs, with slightly higher rates at maximum doses

Often referred to as the 'satiety hormone', leptin signals to the brainspecifically the hypothalamuswhen the body has sufficient energy stores, thereby reducing appetite and increasing energy expenditure

181 Besides, Individual hormonal environments also affect vitamin D and calcium metabolism during weight loss