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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks
Due to serious side effects many cannot be taken long-term
If it looks cloudy or has visible particles after 2 minutes of gentle swirling, something went wrong
(PubMed) Galeone C, Pelucchi C, Levi F, et al
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