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Mechano growth factor is described in muscle physiology research as an early trigger of this activation at the local site of load or injury, distinguishing it from later-acting, differentiation-focused isoforms of IGF-1 such as IGF-1Ea
10.1038/ejcn.2017.132 96 SmeyneM.SmeyneR
Indeed, they did initially pursue it as a potential protectant from UV light-induced skin cancers
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