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The STEP trials demonstrated that semaglutide-treated patients achieved mean weight loss of 15.3% to 17.4% over 68 weeks, compared to 2.4% with placebo
The discontinuation was a business decision, and not due to safety or efficacy issues
Still, it may be relevant to perform pilot studies to address whether the therapy will benefit selected HFrEF cohorts with obesity.
Jardiance's weight loss remains limited because the SGLT2 pathway does not address hunger signals, relying instead on indirect calorie loss through glucosuria (glucose in urine) and metabolic adjustments
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