And on the horizon, with an FDA decision expected by April 10, 2026, is orforglipron, Eli Lilly's next-generation oral GLP-1 that could reshape the entire landscape of medically assisted weight management
You might also hear it called a Herxheimer reaction or JarischHerxheimer reaction the same principle applies: when many pathogens die at once, they release toxins that trigger temporary inflammatory symptoms (source, source)
GnRH agonists can cause menopause-like symptoms, including hot flashes, a tendency to sweat more, vaginal dryness, and, in some cases, a higher risk of osteoporosis
Common side effects may include nausea or fatigue during the first few doses, but these usually subside as your body adjusts