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By keeping the structure so close to the native hormone, the researchers aimed to create a compound that would preferentially bind to the primary target, the MC1R, with minimal spillover to other receptors

Arijs I, Li K, Toedter G et al (2009) Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

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This is in accordance with preclinical studies demonstrating the ventral tegmental area and NAc as key areas mediating the effects of GLP-1 receptor agonists on alcohol intake 10,18