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doi: 10.3389/fnut.2025.1686056 Received 14 August 2025 Accepted 25 September 2025 Published 16 October 2025 Volume 12 - 2025 Edited by Mingyue Song, South China Agricultural University, China Reviewed by Ludovica Verde, University of Naples Federico II, Italy Arely Vergara-Castaeda, La Salle University of Northwest, Mexico Updates Copyright 2025 Chyliska and Maciejczyk

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The backbone amide nitrogen of F34 from the G-site stabilizes the acetamide oxygen position via a hydrogen bond and the phenyl ring of F34 packs edge on with the phenyl group of C1-27

GHRH increases cAMP through Gs protein activation