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In colitis, multiple proinflammatory cytokines within the intestinal tissue abnormally activate STAT3, resulting in intestinal barrier dysfunction, hyperactivation of innate immunity, and enhanced Th17-mediated immune responses, all of which contribute to chronic intestinal inflammation (Chen X
Unlike cisplatin and similarly to other antiarthritic gold drugs, auranofin appears to exert its activity through inhibition of enzyme activities rather than DNA damage
Ferritin is a type of protein in your body that helps you store iron in your tissue
PER1 affects cancer growth and causes an increased rate of ionizing radiation-induced cell death, but it is unclear whether its lack of expression precedes and contributes to cancer development, or is the only source of cancer
