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The story extends beyond biology into behavior, where the impact shows up clearly in the data
SURMOUNT-4 examined what happens when tirzepatide is stopped, and participants who discontinued and switched to placebo regained an average of 14% of the weight they had lost
Common Self-Injection Mistakes That Reduce Semaglutide Effectiveness Injecting into the same spot every week creates scar tissue (lipohypertrophy) that reduces medication absorption and effectiveness over time
This is consistent with central sensitization research more broadly, where initial sensitization episodes lower the threshold for future episodes
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