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Skin should be smooth, and if you are injecting intramuscularly

found that fast escalation to 8 mg produced GI adverse events in 50% of participants, compared to roughly 35% with gradual titration (Rosenstock et al., Lancet, 2023)

Interestingly, although there is no benefit to using metformin to treat NAFLD, metformin seems to be effective for NAFLD-related complications: dose-dependent reduction in hepatocellular carcinoma (HCC) was demonstrated in a large cohort of diabetic Taiwanese patients [51, 52] with a 7% reduction in the risk of HCC per year of metformin use

There was a slightly higher rate of discontinuations among Ozempic patients due to gastrointestinal side effects commonly seen with GLP-1s, such as nausea and vomiting