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The histological score of the synovium was determined according to Krenns score [29]

Interestingly, adult mice with modest isolated elevations in GH and IGF-1 levels have greater lean mass, improved lipid oxidation and glucose clearance 38 , while specific, temporal reductions in GH and IGF-1 in adults have been linked to deleterious metabolic effects, including impaired hepatic insulin action 38 , and reduced -cell mass and function 39

Slow wave sleep disruption increases cerebrospinal fluid amyloid- levels

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