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The mechanism of action involves several complementary pathways: Enhanced insulin secretion : GLP-1 agonists stimulate glucose-dependent insulin release from pancreatic beta cells, meaning insulin is only released when blood glucose levels are elevated, thereby reducing the risk of hypoglycaemia
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Compared to placebo, patients treated with liraglutide lost weight but did not experience less knee pain
Subjects within each dose group received a single dose of sildenafil co-administered with a single dose of IN PT-141 or placebo spray at a 3:1 ratio
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