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The obese ( ob ) gene long known to regulate appetite in rodents was found to encode leptin and was subsequently shown to play a key role in metabolic homeostasis and the starvation response in mammals
Exp Cell Res
However, genome-wide bulk mRNA profiling of kidney tissue offered a way to map the molecular basis of disease development and progression (6, 7)
The rationale is that their mechanisms are additive: local repair support plus systemic cell mobility
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