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Although preliminary regulatory-led analyses of post-marketing data have not found conclusive evidence of a causal link [14], and in the absence of evidence from large, randomised clinical trials, observational studies adequately designed to assess the comparative safety of treatments, employing an active comparator, new user design, are warranted to evaluate the risk of SIS in individuals treated with GLP-1RA
GIP receptor : supports insulin sensitivity and enhances satiety
Participants received liraglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes and later approved for weight management
TABLE 1 Summary of cardioprotective and neuroprotective mechanisms by GLP-1R agonists and SGLT2 inhibitors
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