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doi: 10.1007/s11010-017-3200-0 161 BenderskaNChakilamSHugleMIvanovskaJGandesiriMSchulze-LuhrmannJet al

Fluorouracil, folinic acid, irinotecan and oxaliplatins regimen (FOLFIRINOX) is an important treatment for metastatic pancreatic cancer, and a phase IB/II trial evaluated PEGPH20 in combination with FOLFIRINOX, surprisingly poor outcomes were seen, including greater toxicity and shorter median survival, so greater caution is needed when using hyaluronidase in combination with Oxaliplatin [290]

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