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The SELECT cardiovascular outcomes trial established that semaglutide reduces major adverse cardiovascular events by 20%, providing a strong clinical rationale for treatment that extends beyond weight management alone

Still, its important to know when a digestive slowdown moves from annoying to needs professional attention. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), you should reach out to your healthcare provider if you experience any of the following: You have not had a bowel movement in more than 34 days

Stacking aggressive calorie restriction on top risks severe muscle loss and rebound when you eventually taper

You're preventing future damage while addressing what's already there