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In brain tissue, misfolded proteins such as amyloid-beta and tau can sequester copper ions, creating local copper deficiency while simultaneously generating reactive oxygen species through aberrant metal-protein interactions

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The main types are: Biguanides GLP-1 Receptor Agonists SGLT2 Inhibitors DPP-4 Inhibitors Sulfonylureas Thiazolidinediones Alpha-glucosidase Inhibitors Meglitinides Bile Acid Sequestrants Dopamine Agonists Each type targets a different part of the diabetes problem