Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating tgf-1 mediated protein degradation of hgf
metabolite Ac-LKKTE identified as potentially more active than parent compound Paradoxical finding: Both peptides show biological effects persisting hours to days after administration despite rapid plasma clearance Possible explanations: Tissue retention, active metabolites, or persistent signaling cascade activation Excretion Pathways Limited data exists on excretion for both peptides[22]: Likely renal elimination of peptide fragments Hepatic metabolism may contribute to clearance No accumulation detected in chronic dosing studies (animal models) Combined excretion kinetics have not been characterized in any species The disconnect between short plasma half-lives and prolonged biological effects represents a key area requiring mechanistic clarification for both individual peptides and their combination
doi: 10.3390/nu12051487 394 OakSJJhaR
10.1038/s41416-021-01383-0 Summary Keywords oxidative stress, endogenous antioxidant, exogenous antioxidant, cancer prevention, Mendelian randomization study Citation Zhu J, Lian J, Wang X, Wang R, Pang X, Xu B, Wang X, Li C, Ji S and Lu H (2023) Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study
