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The transmembrane protease-activated receptor 2 (PAR-2), which is expressed on keratinocytes and has an important role in the formation of melanocyte dendrites and the phagocytosis of melanosomes by keratinocytes [129, 130], could also be specifically blocked by compounds to decrease epidermal pigmentation [131]

Cysteine bioavailability: main players and regulators As mentioned above, the bioavailability of cysteine in a cancer cell can influence metabolic fitness and the development of therapy resistance

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NK Cell Cytotoxicity Impairment Natural Killer cells provide first-line immune surveillance without prior antigen sensitisation, making their function critical in immune defence against diabetes