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Transgenic expression of FGF21 in pancreatic acini reduces tissue damage, lipid accumulation, and fibrosis induced by cerulein, all of which were exacerbated in animals lacking FGF21 (221, 266)

These actions can support weight reduction and improved glucose control

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Indeed, the SURPASS-CVOT study, which compares tirzepatide head-to-head with dulaglutide, will likely provide more comprehensive answers (expected by the end of 2024)